Neurobiology of Disease The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease
نویسندگان
چکیده
Meagan J. McManus,2 Michael P. Murphy,3 and James L. Franklin1 1Department of Pharmaceutical and Biomedical Sciences, The University of Georgia College of Pharmacy, Athens, Georgia 30602, 2Center of Mitochondrial and Epigenomic Medicine, Children’s Hospital of Philadelphia, Colket Translational Research Building, Philadelphia, Pennsylvania 19104, and 3Medical Research Council Mitochondrial Biology Unit, Cambridge CB2 0XY, United Kingdom
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Cholinergic neuropathology in a mouse model of Alzheimer's disease
Transgenic mice over-expressing mutant human amyloid precursor protein (PDAPP mouse) develop several Alzheimer’s disease (AD)-like lesions including an age-related accumulation of amyloid-?-containing neuritic plaques. Although aged, heterozygous PDAPP mice also exhibit synaptic and glial cell changes, that is characteristic of AD pathology, no evidence of neurodegeneration has been observed. T...
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